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KMID : 0380020130280010007
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Korean Journal of Biotechnology and Bioengineering
2013 Volume.28 No. 1 p.7 ~ p.12
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Activation of Thromboxane Receptor Mediates Interleukin-8 Expression in Endothelial Cells
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Jeon Hwa-Jin
Kim Su-Ryun
Park Hyun-Joo
Kim Mi-Kyoung
Kim Do-Won
Bae Soo-Kyung
Bae Moon-Kyoung
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Abstract
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Thromboxane A2 (TXA2) is one of major proinflammatory mediators, plays an important role in the development of vascular inflammatory diseases. TXA2 acting through the thromboxane receptor regulates multiple pathways and genes in a variety of cells. In this study, we report that the activation of thromboxane receptor with U46619 increases the interleukin-8 (IL-8) mRNA in vascular endothelial cells. We also demonstrated that U46619 produces the activations of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK), which is required for endothelial IL-8 production. And U46619 enhanced mRNA stability of IL-8 transcripts in endothelial cells. Moreover, inhibition of ERK1/2 or p38MAPK reduced monocyte adhesion to aortic endothelium stimulated by U46619. Therefore, these results suggest that activation of thromboxane receptor promotes the expression of IL-8 via ERK1/2 and p38MAPK activation in endothelial cells.
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KEYWORD
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Thromboxane A2, Thromboxane receptor, Interleukin-8, Vascular endothelial cells
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